Related Papers
Otolaryngology -- Head and Neck Surgery
Panel 4: Recent Advances in Otitis Media in Molecular Biology, Biochemistry, Genetics, and Animal Models
2013 •
Ann Hermansson
Brain Research
Mouse models for human otitis media
2009 •
Qing Zheng
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
Panel 3: Genetics and Precision Medicine of Otitis Media
2017 •
Qing Zheng
Objective The objective is to perform a comprehensive review of the literature up to 2015 on the genetics and precision medicine relevant to otitis media. Data Sources PubMed database of the National Library of Medicine. Review Methods Two subpanels were formed comprising experts in the genetics and precision medicine of otitis media. Each of the panels reviewed the literature in their respective fields and wrote draft reviews. The reviews were shared with all panel members, and a merged draft was created. The entire panel met at the 18th International Symposium on Recent Advances in Otitis Media in June 2015 and discussed the review and refined the content. A final draft was made, circulated, and approved by the panel members. Conclusion Many genes relevant to otitis media have been identified in the last 4 years in advancing our knowledge regarding the predisposition of the middle ear mucosa to commensals and pathogens. Advances include mutant animal models and clinical studies. M...
Frontiers in Pediatrics
New paradigms in the pathogenesis of otitis media in children.
2013 •
Livjot Sachdeva
Acute otitis media (AOM) is a multifactorial disease with a significant socioeconomic impact. The pathogenesis of AOM is attributed to a variety of well-established internal and extrinsic factors. Recent evidence strongly points to bacterial biofilm formation as an important contributor to this disease entity. The nasopharynx is a likely reservoir for infection with subsequent seeding of pathogens to the middle ear via planktonic shedding. Various modalities have been used to directly detect biofilm formation in the middle ear mucosa of children with AOM. Further insights into this disease may lead to new strategies for prevention and treatment.
Korean journal of audiology
Development of animal models of otitis media
Otitis media is defined as inflammation of the middle ear, including the auditory ossicles and the Eustachian tube. Otitis media is a major health problem in many societies. The causes of otitis media includes infection and anatomic/physiologic, host, and environmental factors. In general, otitis media is a childhood disease, and anatomic and physiologic changes have great effects on its development. Thus, in vitro or human experimental studies of otitis media are difficult. Several experimental animal models have been introduced to investigate the pathogenesis and treatment of otitis media. However, none are ideal. The aim of this review is to provide a brief overview of the current status of animal models of otitis media with effusion, acute otitis media, and cholesteatoma. This review will assist determination of the most appropriate animal models of otitis media.
International Journal of Infectious Diseases
Role of innate immunity in the pathogenesis of otitis media
2014 •
Kalai Mathee
Annals of Otology, Rhinology & Laryngology
1. Definitions, Terminology, and Classification of Otitis Media
2002 •
Pearay Ogra
International Journal of Pediatric Otorhinolaryngology
Epidemiology, natural history, and risk factors: Panel report from the Ninth International Research Conference on Otitis Media
2010 •
Howard Hoffman
International Journal Of Community Medicine And Public Health
Otitis media causes and management
Lujain Hefni
Otitis media is a major cause of health care visits across the world, and its complications are significant causes of preventable hearing loss, predominantly in the developing world. They are a group of inflammatory and complex infective conditions that affect the middle ear. They have several different subtypes, and affects primarily children from 3 to 7 years of age. When not treated properly, they can lead to many complications including permanent hearing loss. In this article we will discuss updates on recent scientific developments in the field of otitis media clinical management and research. We conducted this review using a comprehensive search of MEDLINE, PubMed and EMBASE from January 1979 to March 2017. The following search terms were used: otitis media, middle ear infections, pediatric infections, causes of otitis media, treatment otitis media, and prevention of otitis media. Otitis media is one of the most common pathologies in the pediatric age group making it one the m...
OTITIS MEDIA
IJAR Indexing
Acute otitis media and otitis media with effusion are common childhood disorders, a source of significant morbidity, and a leading cause of antibiotic prescription in primary health care. Although effective treatments are available, some shortcomings remain, and thus better treatments would be welcome. Recent discoveries within the field of otitis media research relating to its etiology and pathogenesis have led to further investigation aimed at developing novel treatments. This article provides a review of the latest evidence relating to the understanding of acute otitis media and otitis media with effusion, current treatment strategies, their limitations, new areas of research, and novel strategies for treatment.Middle ear infection (otitis media)
